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Bharat Biotech to begin Phase-1 trials of its intranasal vaccine for COVID-19 in Feb-March

PTI
Updated: January 8th, 2021, 16:43 IST
in Coronavirus, Home News, National, Sci-Tech
0
Nasal Vaccine
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Hyderabad: Bharat Biotech has already got emergency use authorisation of Covaxin from the Drug Controller General of India (DCGI). Now Bharat Biotech has said Phase-1 clinical trials of its new intranasal antidote for the killer virus will begin during February-March this year.

Besides Covaxin, the company has been actively working on developing another vaccine. It has tied up with Washington University School of Medicine in St Louis for the novel ‘chimp-adenovirus’ (Chimpanzee adenovirus), a single dose intranasal vaccine for COVID-19.

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“BBV154 (intranasal COVID-19 vaccine), preclinical testing has been completed for toxicology, immunogenicity and challenge studies. These studies have been conducted in the USA and India. Phase I human clinical trials will commence during Feb-March 2021,” an email reply from the city-based vaccine maker informed this agency. Phase I human clinical trials will be conducted in India, Bharat Biotech added.

The Phase-1 trials will be conducted in Saint Louis University’s Vaccine and Treatment Evaluation Unit, the company sources said. They added Bharat Biotech owns the rights to distribute the vaccine in all markets except USA, Japan and Europe.

Krishna Ella, chairman of Bharat Biotech had earlier said the company is focusing on the intranasal vaccine. This is because the existing vaccines require two dose intramuscular injections. A country like India needs 2.6 billion syringes and needles which may add up to pollution.

An intranasal vaccine will not only be simple to administer but reduce the use of medical consumables such as needles, syringes, etc. It will also significantly impact the overall cost of a vaccination drive.

“One drop of vaccine in each of the nostrils is sufficient,” Ella had said.

According to him, keeping several issues in mind Bharat Biotech tied up with Washington University School of Medicine. He had said Bharat Biotech envisions that it would scale this vaccine to one billion doses, translating into equal number of individuals being vaccinated receiving a single-dose regimen.

Bharat Biotech has successfully completed enrollment of 25,800 volunteers for the Phase-3 trials of its COVID-19 vaccine Covaxin.

 

Tags: Bharat BiotechCovaxinIntranasalMedicinevaccineWashington
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