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New Merck pill could revolutionise fight against Covid-19

Updated: October 11th, 2021, 16:19 IST
in Home News, International, Sci-Tech
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Merck

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Washington: Drugmaker Merck asked Monday US Regulators to authorise its pill against Covid-19. Merck has said that the pill would add an entirely new and easy-to-use weapon to the world’s arsenal against the pandemic.

If cleared by the Food and Drug Administration – a decision that could come in a matter of weeks – it would be the first pill shown to treat Covid-19. All other FDA-backed treatments against the disease require an IV or injection.

An anti-viral pill that people could take at home to reduce their symptoms and speed recovery could prove groundbreaking, easing the crushing caseload on US hospitals and helping to curb outbreaks in poorer countries with weak health care systems. It would also bolster the two-pronged approach to the pandemic: treatment, by way of medication, and prevention, primarily through vaccinations.

The FDA will scrutinise company data on the safety and effectiveness of the drug, molnupiravir, before rendering a decision.

Merck and its partner Ridgeback Biotherapeutic said they specifically asked the agency to grant emergency use for adults with mild-to-moderate Covid-19 who are at risk for severe disease or hospitalisation. That is roughly the way Covid-19 infusion drugs are used.

“The value here is that it’s a pill so you don’t have to deal with the infusion centers and all the factors around that,” said Dr Nicholas Kartsonis, a senior vice-president with Merck’s infectious disease unit. “I think it’s a very powerful tool to add to the toolbox,” he added.

The company reported earlier this month that the pill cut hospitalisations and deaths by half among patients with early symptoms of Covid-19. The results were so strong that independent medical experts monitoring the trial recommended stopping it early.

Side effects were similar between patients who got the drug and those in a testing group who received a dummy pill. But Merck has not publicly detailed the types of problems reported, which will be a key part of the FDA’s review.

US officials continue to push vaccinations as the best way to protect against Covid-19. But with some 68 million eligible Americans still unwilling to get the shots, effective drugs will be critical to controlling future waves of infection.

Since the beginning of the pandemic, health experts have stressed the need for a convenient pill. The goal is for something similar to ‘Tamiflu’, the 20-year-old flu medication that shortens the illness by a day or two and blunts the severity of symptoms like fever, cough and stuffy nose.

Also read: Pfizer vaccine for kids unlikely to be available before November

Three FDA-authorised antibody drugs have proved highly effective at reducing COVID-19 deaths, but they are expensive, hard to produce and require specialty equipment and health professionals to deliver.

Assuming FDA authorisation, the US government has agreed to buy enough of the pills to treat 1.7 million people, at a price of roughly $700 for each course of treatment. That’s less than half the price of the antibody drugs purchased by the US government — over $2,000 per infusion — but still more expensive than many antiviral pills for other conditions.

Merck’s Kartsonis said in an interview that the $700 figure does not represent the final price for the medication.

“We set that price before we had any data, so that’s just one contract,” Kartsonis said. “Obviously we’re going to be responsible about this and make this drug as accessible to as many people around the world as we can.”

Several other companies, including Pfizer and Roche, are studying similar drugs and are expected to report results in the coming weeks and months. AstraZeneca is also seeking FDA authorisation for a long-acting antibody drug intended to provide months of protection for patients who have immune-system disorders and do not adequately respond to vaccination.

 

Tags: AntibodyAstraZenecaCOVID-19MerckPfizerPillUS
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